Post-Surgical Pain

Magnitude of the Problem

100 million surgeries per year in the US

53 million require analgesics for pain 

Over half of patients report inadequate relief

Survey Results

In a survey of 300 patients1:

86% experienced pain after surgery

75% had moderate/extreme pain post-surgery

74% still had pain after discharge

88% received analgesic medication

80% experienced adverse effects

Need for Improvement

Suboptimal pain management leads to undesirable outcomes:

  • Medical complications
  • Less ambulation
  • Extended length of hospital stay

Considerable emotional suffering

Significant extra costs

Despite heightened awareness and clinical advancements in pain management, there has been little improvement in post-surgical analgesia as measured by this survey of post-surgical patients.

In pre-clinical and clinical studies, the endomorphins have demonstrated potent anti-nociceptive effects, major anti-inflammatory effects, lack of respiratory depression, little to no addiction potential, less impact on constipation and cannot be converted to drugs of abuse.

In one study it was shown that the endomorphin was associated with a significant reduction in the number of days to recovery from pain after surgery. CYT-1010 is the leading endomorphin in clinical development.

1 Tong J. Gan, Ashraf S. Habib, Timothy E. Miller, William White & Jeffrey L. Apfelbaum (2014) Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey, Current Medical Research and Opinion, 30:1, 149-160, DOI: 10.1185/03007995.2013.860019